International projects

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Current

ENVIRANT - Environmental impact of anthelmintics in livestock and alternatives to minimize their use
Duration:	10. 10. 2024 - 9. 10. 2028
Evidence number:	CA23154
Program:	COST
Project leader:	MVDr. Váradyová Zora, PhD
SAS cosolvers:	RNDr. Batťányi Dominika, PhD., Mgr. Bombárová Alexandra, RNDr. Čobanová Klaudia, PhD., MVDr. Leško Matej, Ing. Petrič Daniel, PhD., MVDr. Váradyová Zora, PhD
Annotation:	Livestock production systems are key in promoting sustainable agricultural practices across Europe. However, these systems have some drawbacks, particularly regarding animal health, as grazing animals are highly susceptible to infections caused by gastrointestinal nematodes. Infections can represent a significant economic burden and their control is administering anthelmintics, posing significant environmental risks. The ENVIRNAT project aims to consolidate and disseminate research and knowledge on the occurrence and ecological impacts of anthelmintics administered to livestock in the environment, and to propose more sustainable practices and methods to minimize their use in the control of helminth infections.
Partner countries:	Belgium, Croatia, Czech Republic, Denmark, France, Germany, Greece, Ireland, Israel, Italy, Latvia, Lithuania, Montenegro, Netherlands, North Macedonia, Norway, Poland, Portugal, Romania, Serbia, Slovenia, Sweden, Turkey, United Kingdom
Project website:	https://www.cost.eu/actions/CA23154/

AFFECT-EVO - An Evolutionary View to Understanding Affective States across Species
Duration:	10. 10. 2024 - 9. 10. 2028
Evidence number:	CA23106
Program:	COST
Project leader:	RNDr. Košťál Ľubor, CSc.
Annotation:	Understanding the affective states (emotions and moods) of non-human animals is crucial to understand their needs, improve their welfare, and assess the effects of treatments for affective disorders in animals, be they preclinical models of human disorders, or patients in their own right. Existing knowledge regarding affective states across species is limited and fragmented. For example, it is unclear: (1) whether and to what extent different affective states occur in different species; (2) if these states are expressed and experienced in similar ways by different species; (3) which physiological mechanisms of affective states are shared across species; and (4) which indicators of affective states are valid across more than one species.AFFECT-EVO brings together an interdisciplinary network of scholars in philosophy, psychology, humanities, social, computational, and natural sciences, with relevant stakeholders from industry, advocacy organizations, and governments. This network will apply an evolutionary framework to evaluate collaboratively and systematically what we know about affective states in non-human animals. This approach will (1) identify gaps in our knowledge, guiding future research; (2) provide a basis for developing strategies to reliably generalize knowledge about affective states across species; (3) develop better methods to assess affective states to improve animal welfare; and (4) develop better treatments for both animal and human affective disorders. We will also explore how the public and policy makers engage with the concept of affective states in animals and how this interacts with the implementation of new laws and policies that affect animals.
Partner countries:	Albania, Croatia, Cyprus, Denmark, Estonia, France, Germany, Greece, Hungary, Iceland, Ireland, Italy, Latvia, Lithuania, Netherlands, North Macedonia, Poland, Portugal, Romania, Serbia, Slovakia, Slovenia, Spain, Sweden, Switzerland, Turkey, United Kingdom
Project website:	https://www.cost.eu/actions/CA23106/

SENESCENCE2030 - Targeting Cell Senescence to Prevent Age-Related Diseases
Duration:	3. 10. 2024 - 2. 10. 2028
Evidence number:	CA23119
Program:	COST
Project leader:	Mgr. Bágeľová Poláková Silvia, PhD.
Annotation:	The challenge to extending the human health span is to prevent or alleviate ageing-associated diseases collectively rather than individually.The knowledge of cellular and molecular mechanisms identified as “hallmarks of ageing” allows experimental strategies to prevent ageing anticipation and extend the health span. A body of evidence indicates that cell senescence is a targetable hallmark of ageing, typically associated with metabolic disorders, cardiovascular diseases, neurodegeneration and cancer.
Partner countries:	Austria, Bosnia and Herzegovina, Cyprus, Czech Republic, Denmark, France, Germany, Greece, Hungary, Ireland, Italy, Latvia, Norway, Poland, Portugal, Romania, Serbia, Slovenia, Spain, Sweden, Turkey, United Kingdom

TREASURE - Maternal Perinatal Stress and Adverse Outcomes in the Offspring: Maximising infants´development
Duration:	9. 11. 2023 - 8. 11. 2027
Evidence number:	CA22114
Program:	COST
Project leader:	prof. RNDr. Lacinová Ľubica, DrSc.
Annotation:	High levels of maternal perinatal stress are associated with negative effects in the offspring. The adverse impact maternal stress can have in the infants´s health is 1) in the short term (prematurity, low infant birthweight); 2) the long-term (neuroinflamation, autism); 3) the very long-term (transgenerational effects). Previous studies have reported maternal stress can have transgenerational consequences. During pregnancy, high levels of maternal stress can cross the placenta and reach the fetus. Mediators responsible for the impact of maternal stress in the developing fetus include cytokines, tryptophan, cortisol, cathecolamines, reactive oxygen species, oxidative stress and microbiota. These mediators, along with epigenetic mechanisms, are involved on the adverse consequences high levels of maternal stress can have in the offspring.In order to improve fetal development and boost infant´s health throughout their lifespan, the TREASURE project aims to consolidate a multidisciplinary and international network of scientists, clinicians, students, stakeholders, Non-Governmental Organisations(NGOs) and Enterprises to achieve impact through a three-fold main objective : 1) discovering, reviewing and disseminating scientific evidence on minimize, reduce and prevent the impact of maternal perinatal stress on fetal development, and to improve psychological, medical and neural development in the offspring during their life-span; 2) bridging knowledge, evidence and experience between scientific disciplines, and bringing international research groups together to increase knowledge exchange between countries. 3) forming international coalitions to efficiently translate scientific knowledge into clinical guidelines and best practices across Europe to improve the health of children, and reducing economic cost appearing from high levels of maternal perinatal stress.
Partner countries:	Germany, Israel, Italy, Luxembourg, Netherlands, Slovakia, Slovenia, Sweden, Switzerland, United Kingdom
Project website:	https://e-services.cost.eu/action/CA22114

MedPlants4Vet - Medicinal plants for animal health care: Translating tradition into modern veterinary medicine;
Duration:	12. 10. 2023 - 11. 10. 2027
Evidence number:	CA22109
Program:	COST
Project leader:	MVDr. Plachá Iveta, PhD
SAS cosolvers:	RNDr. Bačová Kristína, PhD., Mgr. Krištofová Radoslava, MVDr. Pogány Simonová Monika, PhD, MVDr. Zábolyová Natália
Annotation:	The COST Action MedPlants4Vet will create an unprecedented European network of scientists and young researchers and stimulate research activities in different fields of phytochemistry, ethno- and phytopharmacology, pharmacognosy and clinical trials.
Partner countries:	Austria, Belgium, Bulgaria, Croatia, Czech Republic, France, Germany, Greece, Hungary, Italy, Lithuania, Netherlands, Poland, Portugal, Slovakia, Slovenia, Spain, Switzerland, United Kingdom
Project website:	https://www.cost.eu/actions/CA22109/

SafeGameMeat - Safety in the Game Meat chain
Duration:	29. 9. 2023 - 28. 9. 2027
Evidence number:	Cost Action CA22166
Program:	COST
Project leader:	MVDr. Lauková Andrea, CSc.
SAS cosolvers:	MVDr. Bino Eva, PhD., MVDr. Pogány Simonová Monika, PhD, RNDr. Ščerbová Jana, PhD., MVDr. Zábolyová Natália
Annotation:	The main aim and objective of the Action is to determine differences and similarities between European countries in terms of hunting practices, game meat processing and inspection, game meat commodity flows, trade and game meat consumption, investigating all stages of the supply chain from the wild animals to the consumers, "from forest to fork".
Partner countries:	Austria, Belgium, Bulgaria, Croatia, Czech Republic, Denmark, Finland, France, Germany, Greece, Hungary, Italy, Lithuania, Netherlands, Poland, Portugal, Romania, Serbia, Slovenia, Spain, Turkey

EUPAHW - European Partnership on Animal Health and Welfare
Duration:	1. 1. 2024 - 31. 12. 2026
Evidence number:	101136346 — EUPAHW — HORIZON-CL6-2023-FARM2FORK-01
Program:	Horizont Európa
Project leader:	RNDr. Košťál Ľubor, CSc.
SAS cosolvers:	RNDr. Bilčík Boris, PhD., Mgr. Pichová Katarína, PhD.
Annotation:	The European Partnership on Animal Health and Welfare (represented by the acronym EUPAHW) is by far the most ambitious research and innovation initiative the European Commission (EC) has funded to control infectious diseases of animals, and to promote animal welfare. Launched this year (2024), the innovative Partnership is anticipated to invest €360 million over seven years to boost research and facilitate cooperation between all actors. The scope goes beyond the animal health and welfare actors to enhance cross sector collaboration and, through a One Health and One Welfare approach, to provide societal impact. The objectives of the EUP AH&W align with the European Green Deal and its associated Farm to Fork strategy for a fair, healthy, and environmentally friendly food system.
Partner countries:	Austria, Belgium, Denmark, Estonia, France, Germany, Greece, Ireland, Italy, Latvia, Lithuania, Netherlands, Norway, Poland, Portugal, Slovakia, Slovenia, Spain, Sweden
Project website:	https://www.eupahw.eu/index.html

Postbiotics and their effectiveness in horses
Duration:	1. 1. 2025 - 31. 12. 2026
Evidence number:	PAS-SAS-2024-03
Program:	Bilaterálne - iné
Project leader:	MVDr. Lauková Andrea, CSc.
SAS cosolvers:	MVDr. Bino Eva, PhD., MVDr. Pogány Simonová Monika, PhD, MVDr. Zábolyová Natália
Annotation:	The aim of the project is to study the possible beneficial effect of postbiotic-bacteriocins in horse breeds in Slovakia/Poland.
Partner countries:	Poland

LipAI - Lipid Regulation for Anti-Inflammatory Therapy
Duration:	1. 1. 2024 - 31. 12. 2026
Evidence number:	SAS-NSTC-JRP-2023-04
Program:	JRP
Project leader:	Mgr. Balážová Mária, PhD.
SAS cosolvers:	RNDr. Bábelová Lenka, PhD., Mgr. Ďurišová Ivana, Mgr. Valachovič Martin, PhD., Mgr. Zriniová Ingrid
Annotation:	Bacterial or viral infections can activate inflammatory processes. High-affinity inhibitory interactions between the anionic phospholipids in pulmonary surfactant and TLRs suggests that these lipids play a crucial role in regulating infectious and innate immune processes. This proposal aims to investigate the role of lipid regulation in microbial infection and host defense responses. Anionic lipids, such as phosphatidylglycerol(PG) and phosphatidylinositol(PI), are proposed to act as bait ligands for TLRs and viral attachment proteins. The therapeutic potential of valproic acid (VPA) in inducing the synthesis of PG in pulmonary surfactant, which could suppress inflammatory responses, will be investigated. The human alveolar basal epithelial cell line A549 and pro-monocytic model cell line U937 will be utilized to address these inflammatory responses. Additionally, the study investigates methods for preventing the transition from acute to chronic inflammation and subsequent neuroinflammation. PG, PI, and anti-inflammatory eicosanoids will be tested as potential therapeutic agents to prevent neuro-inflammation.
Partner countries:	Taiwan

LIFT - Lifting farm animal lives – laying the foundations for positive animal welfare
Duration:	4. 11. 2022 - 3. 11. 2026
Evidence number:	CA21124
Program:	COST
Project leader:	RNDr. Košťál Ľubor, CSc.
SAS cosolvers:	Mgr. Pichová Katarína, PhD.
Annotation:	The main aim and objective of the Action is to define and conceptualise positive animal welfare, to identify valid methodologies to assess positive animal welfare, to assess the understanding and acceptance of this concept, and to suggest potential animal- and resource-based indicators of positive welfare to be monitored on farm.
Partner countries:	Albania, Austria, Belgium, Bosnia and Herzegovina, Croatia, Czech Republic, Denmark, Estonia, France, Germany, Greece, Ireland, Israel, Italy, Latvia, Lithuania, Netherlands, North Macedonia, Norway, Poland, Portugal, Romania, Serbia, Slovenia, Spain, Sweden, Switzerland, Turkey, United Kingdom
Project website:	https://liftanimalwelfare.eu/

TRANSLACORE - Translational control in Cancer European Network
Duration:	4. 10. 2022 - 3. 10. 2026
Evidence number:	COST Action CA21154
Program:	COST
Project leader:	Mgr. Messingerová Lucia , PhD.

GenE-Humdi - Genome Editing to Treat Humans Diseases
Duration:	15. 9. 2022 - 14. 9. 2026
Evidence number:	COST Action CA21113
Program:	COST
Project leader:	MMedSc Dremencov Eliyahu, DrSc
SAS cosolvers:	prof. PharmDr. Ježová Daniela, DrSc.

ANDRONET - European Andrology Network – Research Coordination, Education And Public Awareness
Duration:	27. 10. 2021 - 26. 10. 2025
Evidence number:	COST Action CA20119
Program:	COST
Project leader:	RNDr. Antalíková Jana, PhD.
SAS cosolvers:	Ing. Jankovičová Jana, PhD.
Annotation:	ANDRONET aims to boost research collaboration, education and public awareness in andrology, a field of science that deals with male health. Currently there are no European- or world-wide networks through which researchers and clinicians in andrology can interact. The need for such a network is urgent due to the increasing incidence of infertility and testicular cancer, worrying reports of an association of poor reproductive function with poor health, and male predisposition to serious diseases, including Covid-19, leading to shorter life expectancy in men. Male infertility is common, but the patients are currently treated through assisted reproduction technology with primary burden on women. The aetiology of male reproductive problems is heterogeneous and comprises complex interactions between multiple genes andepigenetic factors, with largely unknown impact of environmental factors including infections. This COST Action proposes to increase multidisciplinary research collaboration and data exchange among andrology centres, and transfer of knowledge to European countries with less developed research. The initial consortium includes centres comprising complementary clinical and research expertise at a very high level, but ANDRONET will expand to reach a critical mass necessary for obtaining new knowledge and its possible commercial exploitation across Europe. ANDRONET aims to improve professional education in andrology which is fragmented among several medical branches and will contribute to the recognition of andrology as a medical subspecialty at European level. ANDRONET will strive to properly inform the public with evidence-based knowledge and thereby increase awareness of increasing male health problems and contribute to development of preventive measures.
Partner countries:	Albania, Austria, Belgium, Bosnia and Herzegovina, Bulgaria, Croatia, Czech Republic, Denmark, Estonia, Finland, France, Germany, Greece, Hungary, Ireland, Israel, Italy, Latvia, Lithuania, Malta, Moldova, Montenegro, Netherlands, North Macedonia, Norway, Poland, Portugal, Serbia, Slovenia, Spain, Sweden, Switzerland, Turkey, United Kingdom
Project website:	https://www.cost.eu/actions/CA20119/

BETTER - Biosecurity enhanced through training evaluation and raising awareness
Duration:	21. 10. 2021 - 20. 10. 2025
Evidence number:	CA20103
Program:	COST
Project leader:	MVDr. Lauková Andrea, CSc.
SAS cosolvers:	MVDr. Bino Eva, PharmDr. Focková Valentína, PhD., MVDr. Grešáková Ľubomíra, PhD., MVDr. Pogány Simonová Monika, PhD, RNDr. Ščerbová Jana, PhD., Ing. Tokarčíková Katarína, PhD.
Annotation:	Biosecirity is a paramount importance to prevent the introduction and spread of pathogens and, consequently, to preserve health of farmed animals. Healthier animals result in better animal wellfere, better sustainability of animal production systems and less antimicrobial use. Despite these benefits, biosecurity is limited by different factors: lack of knowledge on ways for improvement, especially in extensive systems or settings with low resources, shortage of adequate ways to enhance communication, diversity methodologies and their cost-effectiveness, low number of trained professionals. To approach these challanges, project will evaluate how biosecurity is currently used and will use participative approaches to understand motivators and barriers for biosecurity implementation. Action will also compare existing methods and will identify which points has to be more trained and will develop courses for increase of professionals. Action will recommend priority research areas for future biosecurity improvement in animal production systems which will be reached via transdisciplinary group of investigators.
Partner countries:	Albania, Austria, Belgium, Bulgaria, Croatia, Denmark, Estonia, Finland, France, Germany, Greece, Ireland, Italy, Netherlands, North Macedonia, Norway, Poland, Portugal, Serbia, Slovenia, Sweden, Turkey, United Kingdom

Finished

Molecular and physiological properties of honeybee royal jelly proteins
Duration:	1. 4. 2021 - 31. 3. 2025
Evidence number:
Program:	Bilaterálne - iné
Project leader:	RNDr. Bíliková Katarína, PhD.
Annotation:	Study of physiologically active proteins and peptides of honeybee products, especially honeybee jelly and honey, with the aim of applying the results of the research in human medicine and nutrition
Partner countries:	Japan